웹2024년 10월 12일 · Efficacy of neoadjuvant anti-PD-1+anti-CD137 is dependent on Batf3 + DCs and type I IFN. It has been shown that innate immune sensing of tumors occurs through activation of the STING pathway, which leads to type I interferon (IFN) production, dendritic cell (DC) activation, cross-presentation of tumor-associated antigens to CD8 + T cells, and … 웹2012년 7월 13일 · In vivo, cross-presentation is mainly carried out by specific dendritic cell (DC) subsets through an adaptation of their endocytic and ... K. et al. Batf3 deficiency …

Nature：BATF3改善T细胞记忆应答，有望改善免疫疗法的疗效

웹7. batf3−/−小鼠：缺乏cd103+ 树突状（dc）细胞，抗原呈递能力受损。 8.小鼠胰腺原位肿瘤模型。 结果分析. 1. mhc-i富集于pdac细胞溶酶体中，且在细胞膜上表达减少。 作者研究发现 … 웹Batf3 is a transcription factor that impacts the development of CD103 + tissue-resident dendritic cells (DCs). However, whether Batf3 is absolutely required for the development of … link isa charges

Interleukin-12 from CD103+ Batf3-Dependent Dendritic Cells …

웹2024년 3월 22일 · Based on their specialized functional properties, DC subsets can affect tumor development and progression via various mechanisms, depending on dynamic … 웹2024년 12월 6일 · Stimulatory dendritic cells (SDC), enriched within Batf3-DC (cDC1), engage in productive interactions with CD8+ effectors along tumor-stroma boundaries. The paradoxical accumulation of “poised” cross-presenting Batf3-DC within stromal sheets, distal to tumoral nests, is unlikely to simply reflect passive exclusion away from immunosuppressive tumor … 웹2013년 6월 21일 · Thus, the ability of BATF2 to functionally compensate for BATF3 in DC development suggests that BATF2–JUN heterodimers might exclusively bind to an AICE, … hounds around town mobile groomers