WebApr 26, 2011 · Microorganism-derived polyene polyketides have been shown to display a variety of biological activities and have attracted great interest due to their structurally intriguing chemical diversity. Two new polyenes were isolated from a culture broth of Streptomyces sp. KMC-002 obtained from a soil sample in an abandoned mine. The … WebThe biosynthesis of polyketides from acyl-CoA thioesters is catalyzed by polyketide synthase (PKS), a multi-enzyme complex that is highly homologous to fatty acid synthase (FAS). This chapter will focus on the structural enzymology of the Type II PKS enzymes that are responsible for the synthesis of aromatic polyketides such as actinorhodin ...

Cyclization of aromatic polyketides from bacteria and fungi

WebA small group of P450 enzymes were identified to form a benzene ring from an acyclic polyene substrate in the biosynthesis of lorneic acid and other trialkyl-substituted … WebMay 5, 2009 · 2. PROTEIN SUBUNITS OF TYPE II PKSs. Methods for genetic manipulation of Gram–positive actinomycetes, pioneered by D. A. Hopwood and coworkers, 7, 8 … nutcracker ballet full performance

Insights into the Role of Ketoreductases in the …

WebCovering: up to the end of 2009 This review discusses the enzymatic basis of the different cyclization strategies used by bacteria and fungi in the biosynthesis of aromatic polyketides. WebAromatic polyketides make up a large class of natural products with diverse bioactivity. During biosynthesis, linear poly-β-ketone intermediates are regiospecifically cyclized, yielding molecules ... WebNov 10, 2000 · Aromatic polyketides differ from other polyketides by their characteristic polycyclic aromatic structures. These polyketides are widely distributed in bacteria, fungi, and plants, and many of them are clinically valuable agents or exhibit other fascinating … The first volume covered the use of isotopes in biosynthetic research and … nutcracker ballet george balanchine